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Contraindicated (1)pentobarbital will lessen the extent or outcome of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or impact of lapatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lessen the level or impact of darifen